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mavorixafor will raise the level or effect of codeine by influencing hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a strong CYP2D6 inhibitor) is contraindicated with prescription drugs which have been really dependent on CYP2D6 for clearance.benzhydrocodone/acetaminophen and codeine both boost sedation. Prevent or Use Alternate Dr